OS analysis of patients with stage IV disease, by marrow status. (A) OS by PET. Patients with marrow involvement detected by PET had similar OS to those individuals with stage IV disease without an involved marrow. (B) OS by BMB. Patients with positive marrow involvement by histology had significantly inferior OS compared with patients with negative histology. neg, negative; PET, positron emission tomography; pos, positive. Adapted from Figure 4 (panel A from 4B; panel B from 4D) in the article by Khan et al that begins on page 61.