Genomic aberrations in RS. Frequency of DNA gains (red, up) and losses (blue, down) observed in 315 cases of CLL-U (A), 28 cases of CLL-phase of RS (B), 58 cases of RS (C), and 127 cases of de novo DLBCL (D); representation of the focal gains (left) and losses (right) as detected via GISTIC in RS samples (E). (A-D) X-axis represents chromosome localization and physical mapping and y-axis the proportion of cases showing the aberrations. (E) False-discovery rate q values are plotted along the X-axis with chromosomal position along the Y-axis; altered regions with significant levels exceeding the vertical green line (significance threshold) were deemed significant; chromosomal positions are shown for each significant region on the right side of the plots.