Examples of unbalanced genomic aberration acquired at the transformation in three paired CLL-phase and RS samples. Black arrows highlight losses at 9p (CDKN2A; pt#97, pt#203) and 17p (TP53; pt#203, pt#72) and an amplification at 9p (JAK2; pt#72). Black dots, raw CN values; red line, smoothed CN values. X-axis, genomic mapping; Y-axis, log2 copy-number values.