Heatmap with the relative distribution of the most common lesions detected in RS samples (A), Kaplan-Meier graph showing OS in 24 RS patients according to the presence of TP53 inactivation and/or CDKN2A loss (B). (A) Red, presence; gray, absence; white, not available; cell proliferation (as measured by assessment of the percentage of Ki-67⁺ cells at immunohistochemistry) is also visualized. (B) X-axis, months; Y-axis, percentage of alive patients. The spikes on the survival curves indicate the censored patients.