Figure 4
![Figure 4. Lyl1 is required for Lmo2-driven leukemogenesis. (A) Normalization of gene expression in Lmo2;Lyl1−/− thymocytes. A heat map shows the expression levels of the top 40 Lmo2-upregulated genes in wild-type (wt), Lmo2-transgenic (Tg), and Lmo2;Lyl1−/− DN thymocytes. (B) A heat map shows the expression levels of the top 40 Lmo2-downregulated genes in DN thymocytes of mice of the indicated genotypes. Labels are as in (A). (C) Kaplan-Meier survival curve of mice of the indicated genotypes. P < .001 between Lmo2;Lyl1+/− and Lmo2;Lyl−/− (log-rank [Mantel-Cox] test).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/122/12/10.1182_blood-2012-09-458570/4/2093f4.jpeg?Expires=1735483075&Signature=32bYPmriibT2WM2hFXMOO9stPWVluBsajUnLEiMCez7aQ12Av0BeKmvTa5flzOJy2uLs~fJhTWRwVd25MzXwOVczZz5Oj4hnug2IuZCqKpZqy8gI1pfdetQ5JmfucGF52GYngFjF~0EgJ8fKcBOJMCnh3ncZe-oGaD-Hiowig0RDFGv70I63nPvnbkzSBwrLC~Jl9fpFKUSOWO9dqucokPWM3VC4Ar~vUI8kW9oxf26SdOH-O4op7brnW0VMCIg4XIPguvoxb~0c9D0OPb3khPN5nkRGJdyC8EkSEBxsOfUm5HP-7T71Hul7jAger~SS1u8Yn8hkDsTvBnY9pqrUnA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Lyl1 is required for Lmo2-driven leukemogenesis. (A) Normalization of gene expression in Lmo2;Lyl1−/− thymocytes. A heat map shows the expression levels of the top 40 Lmo2-upregulated genes in wild-type (wt), Lmo2-transgenic (Tg), and Lmo2;Lyl1−/− DN thymocytes. (B) A heat map shows the expression levels of the top 40 Lmo2-downregulated genes in DN thymocytes of mice of the indicated genotypes. Labels are as in (A). (C) Kaplan-Meier survival curve of mice of the indicated genotypes. P < .001 between Lmo2;Lyl1+/− and Lmo2;Lyl−/− (log-rank [Mantel-Cox] test).
