Subclonal representation of recurrent somatic mutations. Genes containing cSNVs in 2 or more diagnostic specimens within this study exhibit different patterns of representation between CD20int and CD20hi subpopulations. The top panel shows the recurrence frequency of mutations within each gene in our cohort. The bottom panel shows the fraction of those mutations that are represented approximately equally (≤ 33% deviation; green) between each subpopulation, those that show skewed representation (> 33% deviation; purple), and those that are identified exclusively in one subpopulation and not the other (gray). It can be seen that cSNVs in the majority of genes show skewed or unequal representation between tumor subpopulations, and CREBBP mutations are the only variants that are equally represented between subpopulations in all instances.