Genetic features of cyclin D1⁻ MCL. (A) FISH analysis shows CCND2 breaks in patient ID36. (B) FISH image shows an IGL-CCND2 fusion in patient ID36. (C) FISH image shows and IGK-CCND2 fusion in patient ID28. Frequency of genetic alterations in CCND2 translocation–positive (D; n = 17) and CCND2 translocation–negative (E; n = 15). On the x-axis, the chromosomes are represented horizontally from 1-22; on the y-axis, the percentages of patients with CNAs are shown. Gains are represented on the positive y-axis and colored in blue and losses are represented on the negative y-axis in red.