Identification of T-cell–associated miRNA signature. (A) The 6-miRNA signature differentially expressed (P < .01; greater than fourfold change) in normal T cells compared with B-cell subsets and stromal cells. (B) Expression of T-cell miRNA signature in different subtypes of T-cell and B-cell lymphomas. A majority of PTCL cases (including ALK(+) ALCL, ALK(–) ALCL, AITL, and PTCL-NOS) and a few DLBCL cases showed enrichment of T-cell miRNA as well as stromal-cell miRNA signatures. (C) Overlap in the expression of the top 10% of miRNAs from CD3⁺ T cells, ALK(+) ALCLs, and ALK(–) ALCLs. BL, Burkitt lymphoma; MCL, mantle cell lymphoma.