Proposed algorithm for MCL treatment. *Fever, bone pain, flushing, mast cell activation symptoms, cardiac failure, pleural effusion, ascites, cytopenia. **If available through a compassionate patient-named program. #Examples of drugs for clinical studies: cytarabine + 2-chlorodeoxyadenosine (2-CdA); CLAG (clofarabine, aracytine, granulocyte stimulating agents); FLAG (fludarabine, aracytine, granulocyte stimulating agents); tyrosine kinase inhibitors (midostaurin, masitinib, ponatinib, sorafenib), or Aurora kinase inhibitors in combination with other drugs; mammalian target of rapamicin (m-TOR) inhibitors; deoxy nucleotide methyl-transferase inhibitors (azacytidine, decitabine).