Distribution of methylation values for a representative primary AML sample (721214) relative to gene and CpG island annotations, and expression. (A) Methylation value distributions for CpGs in promoters (green), gene bodies (orange), 3′ untranslated regions (purple); the distribution for all genic CpGs is shown in black. (B) Methylation value distributions for CpGs in islands (green), within 2 kbp of islands (orange), 2 to 4 kbp from islands (purple), and outside of islands (black). (C) Methylation value distributions for CpGs in promoters of genes stratified by array-based expression quartile. (D) Methylation value distributions for all genic CpGs stratified by array-based expression quartile.