Effects of short-term DAC treatment on primary AML samples. (A) Distribution of methylation values for all interrogated CpGs from 8 primary AML samples treated with DAC (blue), cytarabine (red), or DMSO (black). (B) Change in methylation values on treatment with DAC, versus methylation in mock-treated samples, for a representative primary AML sample (721214). (C) Hierarchical clustering of methylation values of 8 primary AML samples treated with DAC, AraC, or vehicle using the 1000 most variable CpGs across all arrays.