Genomic aberrations in ALCL samples. (A) Frequency of DNA gains (up) and losses (down) observed in 64 systemic ALCL (top panel), 31 ALK⁻ALCL (middle panel), and 33 ALK⁺ALCL samples (bottom panel). Red represents gains and blue represents losses. X-axis represents chromosome localization and physical mapping; y-axis, proportion of cases showing the aberrations. (B-C) Representation of focal aberrations in ALCL samples. Analysis via GISTIC of copy number gains (left) and losses (right) for the 64 ALCL samples and only for the 31 ALK⁻ALCL samples. False-discovery rate q values are plotted along the x-axis with chromosomal position along the y-axis. Altered regions with significant levels exceeding the vertical green line (significance threshold) were deemed significant. Chromosomal positions are shown for each significant region on the right side of the plots.