Docking of warfarin to the homology modeled hVKORC1 structure. (A) A ribbon diagram of the hVKORC1 homology model with docked warfarin depicted as red balls. Interactions between warfarin and hVKORC1 interface residues are represented as solid lines (hydrophobic and π-interactions). (B) A ligplot representation of the interactions between warfarin and amino acid residues of hVKORC1. Hydrogen bonds are indicated by dotted lines and hydrophobic contacts are represented by arcs with spokes radiating toward the contact atoms.