Figure 2
![Figure 2. Neutropenia-induced feedback in NSG mice. (A) NSG mice received 1A8, RB6-8C5, or PBS. Flow cytometric analyses of marrows are shown. Note the significant changes of LSK, GMP, and MEP. (B) Absolute cell numbers in both femora and tibiae of NSG mice (n = 5). RB6-8C5: p(LSK) = 0.04; p(GMP) = 0.05; p(CMP) < 0.001; p(MEP) = 0.02; 1A8: p(LSK) < 0.001; p(GMP) = NS; p(MEP) = NS; p(CMP) = NS. (C) Plasma G-CSF and M-CSF levels in control and antibody-treated NSG mice. Note significant change of G-CSF [n(control) = 4; n(RB6-8C5) = 3; n(1A8) = 3]. G-CSF: p(RB6-8C5) = 0.003; p(1A8) < 0.001; M-CSF: p(1A8 and RB6-8C5) = NS.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/121/5/10.1182_blood-2012-05-429589/4/zh89991301520002.jpeg?Expires=1735807122&Signature=ya0VvlSqGcbRt298lRekMKePJSyJyyUzxsedLLjRoSD-vm61QEHKxwWI2QpUN3xr-LzCzg4buGRw6V1cMvpP-UTBZy~vZbEH5qxaGsuCnpBLAM92a8o-MWvSpnIwLxVRHvylRkeAUVf5Ued-Jc2gw~QU6E4IE~17H4HcSldIvpUMqyCl83WOppczYlfHHfd1E7h-8~E8iALS4O0sY0Gd7dbWN~41T3r1jR61UcYQfcamgk2UxUmcROwGBPHpcIT2ECeBmpn4AZ21OJasf0~MWU4-AQB-OpZCXkPfacDNbG2IA42Amet5LZzXbB7~BS12NzS69f0AXta0-RI5UVZJRQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Neutropenia-induced feedback in NSG mice. (A) NSG mice received 1A8, RB6-8C5, or PBS. Flow cytometric analyses of marrows are shown. Note the significant changes of LSK, GMP, and MEP. (B) Absolute cell numbers in both femora and tibiae of NSG mice (n = 5). RB6-8C5: p(LSK) = 0.04; p(GMP) = 0.05; p(CMP) < 0.001; p(MEP) = 0.02; 1A8: p(LSK) < 0.001; p(GMP) = NS; p(MEP) = NS; p(CMP) = NS. (C) Plasma G-CSF and M-CSF levels in control and antibody-treated NSG mice. Note significant change of G-CSF [n(control) = 4; n(RB6-8C5) = 3; n(1A8) = 3]. G-CSF: p(RB6-8C5) = 0.003; p(1A8) < 0.001; M-CSF: p(1A8 and RB6-8C5) = NS.
