Expression of noncoding RNAs in human CD34⁺HSPCs is associated with heptad binding. (A) Binding peaks for each TF were evaluated for their proximity to miRNA as outlined in the supplemental Data. The number of binding peaks associated with a miRNA is shown for each TF, and proportions of those with their own promoter (green) and those located within a coding gene (purple) are shown (also see supplemental Figure 7). (B) The numbers of peaks associated with miRNA for combinations involving binding of 2 or more TFs are shown on the left of the figure. Only combinations with at least 2 targets are shown, whereas all combinations are reported in supplemental Table 1. Z scores on the right indicate significant deviation between observed and expected events. The likelihood of miRNA associated regions with 6 or 7 overlapping TFs were overrepresented, whereas regions with 2 and 3 overlapping TFs were underrepresented. (C) Density plots of ChIP-seq reads at the promoter of pri-miR-146a in hCD34⁺ HSPCs displayed in the UCSC genome browser with corresponding miRNA expression. (D) A heat map showing differential expression across cell types for heptad target miRNAs that are expressed in at least 1 of the 3 cell types.