Comparison of the R-FCM with the previous FCM trial.34 (A) Probability of conversion from MRD-negative to MRD-positive in the R-FCM + R and FCM cohorts. (B) TNT in patients who achieved a CR MRD-negative after initial treatment with R-FCM or FCM. (C) TNT in patients who achieved a CR MRD-positive after R-FCM or FCM. (D) TNT in patients who achieved a PR after R-FCM or FCM. (E) MRD kinetics of 11 representative patients of the R-FCM + R cohort. Dotted line box represents period under rituximab maintenance. (F) MRD kinetics of 11 representative patients of the FCM cohort.