Effects of ovx and of the antiestrogen ICI 182780 on the survival of lethally irradiated WT mice transplanted with a limiting number of BM cells derived from WT mice, TCRβ^−/− mice, and TCRβ^−/− mice previously subjected to adoptive transfer of T cells. (A-C) Donor mice were intact. Recipient mice were sham operated or ovx 2 weeks before BM transplantation. (D-F) Donor mice were sham operated or ovx 2 weeks before BM transplantation. Recipient mice were intact. (G) Donor mice were untreated. Recipient mice were treated with vehicle or ICI182780 (100 μg/mouse subcutaneously, twice a week for 4 weeks) starting at the time of transplantation. (H) Donor mice were treated with vehicle or ICI182780. Recipient mice were untreated. n = 10 per group.