Association of SNPs in the GATA3 locus with B-ALL risk among Hispanic children, by subtype. Association of 68 directly genotyped SNPs (black) and 477 imputed SNPs (gray) with B-ALL risk, adjusted for the first 5 principal components. Circles denote associations for B-ALL cases compared with controls. Triangles denote associations for nonhyperdiploid B-ALL cases without TEL-AML1 fusion compared with controls. Haplotype structure in the Hispanic sample appears below gene names, with darker shading indicating higher R² values and greater correlation between SNP genotypes. The strongest association in the Hispanic samples is at rs1271899 located in haplotype block 5. The strongest association from Migliorini et al,¹  rs3824662, is located between blocks 5 and 6 and is weakly but significantly linked to rs1271899 (R², 0.10; P < .0001).