A schematic diagram showing the mechanism by which L5 triggers platelet activation and aggregation. L5 promotes thrombogenesis by increasing endothelial expression of tissue factor and P-selectin, which are prone to enhance platelet adherence and activation. In addition, L5 activates platelets through the receptors LOX-1 and PAFR and enhances ADP-induced signaling. The receptor signaling through LOX-1 and PAFR mediates PI3K/PKC activation, which leads to the phosphorylation of AKT and reduces cAMP levels while promoting the release of granules. P-selectin is expressed on both the surface of platelets and ECs to increase platelet-EC interactions.