Figure 4
Figure 4. The infiltration of AR-DLBCL by CTLs is determined by the viral profile of the tumor. (A) The number of cytotoxic cells against the viral profiles. Cases with viral antigen expression (LMP1 and/or p24) show a substantially higher infiltration by cytotoxic cells than those lacking viral antigens. The P values correspond to activated (granzyme-positive) CTL. Immunohistochemical analysis for granzyme of 4 representative biopsy specimens with different viral profiles: (i) LMP1+ AR-DLBCL, (ii) LMP1−, p24+ AR-DLBCL, (iii) EBER+, LMP1−, p24−, and (iv) EBER−, LMP1−, p24− AR-DLBCL. (B) Additional immunosuppressive pathways in AR-DLBCL: PD1-PDL1 interaction. PD1-positive reactive lymphocytes are adjacent to, but also present within, the tumor whereas tumor cells demonstrate strong expression of the PD1 ligand, PDL1; *infiltrating sheets of tumor. Images were obtained with a Leica DM2500 microscope (original magnification, ×400), Leica DFC320 camera.

The infiltration of AR-DLBCL by CTLs is determined by the viral profile of the tumor. (A) The number of cytotoxic cells against the viral profiles. Cases with viral antigen expression (LMP1 and/or p24) show a substantially higher infiltration by cytotoxic cells than those lacking viral antigens. The P values correspond to activated (granzyme-positive) CTL. Immunohistochemical analysis for granzyme of 4 representative biopsy specimens with different viral profiles: (i) LMP1+ AR-DLBCL, (ii) LMP1−, p24+ AR-DLBCL, (iii) EBER+, LMP1−, p24−, and (iv) EBER−, LMP1−, p24− AR-DLBCL. (B) Additional immunosuppressive pathways in AR-DLBCL: PD1-PDL1 interaction. PD1-positive reactive lymphocytes are adjacent to, but also present within, the tumor whereas tumor cells demonstrate strong expression of the PD1 ligand, PDL1; *infiltrating sheets of tumor. Images were obtained with a Leica DM2500 microscope (original magnification, ×400), Leica DFC320 camera.

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal