Relationship between number of oncogenic mutations and outcome. (A) Leukemia-free survival for patients broken down by how many oncogenic mutations were identified (including both point mutations and cytogenetic lesions). The mean number of cytogenetic lesions per patient was 0.2, 0.4, 0.5, 0.8, and 2.3 for patients with 1, 2, 3, 4 to 5, and 6 or more oncgenic mutations, respectively. The P value denotes the log-rank test of the null hypothesis that all groups had the same leukemia-free survival. (B) Incidence of transformation to acute leukemia broken down by how many oncogenic mutations were identified. (C) Leukemia-free survival for patients with no ASXL1 mutations (gray), “known oncogenic” mutations (blue), and “possible oncogenic” mutations or variants “of unknown significance” (red). The P values refer to log-rank tests comparing the class of mutation to those patients without ASXL1 mutations.