Suggested management for BL in sub-Saharan Africa. *Optimal diagnostic evaluation and definitive treatment will be strongly determined by local expertise, resources, and infrastructure. Treatment on a clinical trial or prospective, longitudinal, cohort study is strongly recommended whenever possible. Concurrent antiretroviral therapy should be administered if HIV-infected. In middle-income countries, high-income country regimens can often be successfully followed. ‡Poor performance status defined as Lansky score ≤50 or Eastern Cooperative Oncology Group (ECOG) score ≥3. Good performance status defined as all others. ‡Low risk defined as all of the following: stage I/II, no abdominal disease, largest tumor bulk <10 cm, and lactate dehydrogenase <2 times upper limit of normal. High risk defined as all others. CSF, cerebrospinal fluid; CT, computed tomography; EBV, Epstein-Barr virus.