Figure 2.
Figure 2. Bone marrow B-cell development in Rag1-mutant mice. (A) Gating strategy for pro-B cells (B220loIgM−CD43+), pre-B cells (B220loIgM−CD43−), immature B cells (B220loIgM+CD43−), and mature recirculating (B220hiIgM+CD43−) cells, shown as percentages of total B220+ cells (B) and absolute numbers (n = 6) (C) for WT, hypomorphic mutant, and KO mice. Gating strategy for pro-pre-BI stage (B220loc-kit+) and pre-BII stage (B220loCD25+) (D) and percentage of these cells among B220+IgM− B-cell precursors (n = 3) (E). Error bars represent standard error of the mean. (B-C,E) One-way analysis of variance: *P ≤ .05, **P ≤ .01, ***P ≤ .001, ****P ≤ .0001.

Bone marrow B-cell development in Rag1-mutant mice. (A) Gating strategy for pro-B cells (B220loIgM−CD43+), pre-B cells (B220loIgM−CD43−), immature B cells (B220loIgM+CD43−), and mature recirculating (B220hiIgM+CD43−) cells, shown as percentages of total B220+ cells (B) and absolute numbers (n = 6) (C) for WT, hypomorphic mutant, and KO mice. Gating strategy for pro-pre-BI stage (B220loc-kit+) and pre-BII stage (B220loCD25+) (D) and percentage of these cells among B220+IgM− B-cell precursors (n = 3) (E). Error bars represent standard error of the mean. (B-C,E) One-way analysis of variance: *P ≤ .05, **P ≤ .01, ***P ≤ .001, ****P ≤ .0001.

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