Figure 2
Figure 2. S1pr2 null mice exhibit less vascular inflammation in the kidney during endotoxemia. Expression of adhesion molecules and procoagulant and proinflammatory markers in kidneys from control WT, LPS-treated WT (WT + LPS), and LPS-treated S1pr2−/− (KO + LPS) mice 18 hours after administration of vehicle or LPS. Immunostaining for (A) E-selectin, (B) VCAM-1, (C) ICAM-1, (D) TF, and (E) MCP-1. Scale bar, 50 μm. Representative fields from 3 to 5 mice are shown. Images were captured with the Axio Imager A1 microscope, using AxioCam MRc camera and the AxioVision 4.8 program (Carl Zeiss Inc.) (original magnification ×40). a, arteriolar endothelium; e, epithelial cell; g, glomerulus; le, leukocyte; ptc, peritubular capillary; v, venule; vs, vascular smooth muscle cell.

S1pr2 null mice exhibit less vascular inflammation in the kidney during endotoxemia. Expression of adhesion molecules and procoagulant and proinflammatory markers in kidneys from control WT, LPS-treated WT (WT + LPS), and LPS-treated S1pr2−/− (KO + LPS) mice 18 hours after administration of vehicle or LPS. Immunostaining for (A) E-selectin, (B) VCAM-1, (C) ICAM-1, (D) TF, and (E) MCP-1. Scale bar, 50 μm. Representative fields from 3 to 5 mice are shown. Images were captured with the Axio Imager A1 microscope, using AxioCam MRc camera and the AxioVision 4.8 program (Carl Zeiss Inc.) (original magnification ×40). a, arteriolar endothelium; e, epithelial cell; g, glomerulus; le, leukocyte; ptc, peritubular capillary; v, venule; vs, vascular smooth muscle cell.

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