Proposed guidelines for management of younger MM patients. CyBorD, cyclophosphamide, bortezomib, dexamethasone; ISS, International Staging System; KRD, carfilzomib, lenalidomide, dexamethasone; PN, peripheral neuropathy; R-ISS, revised International Staging System; RVD, lenalidomide, bortezomib, dexamethasone; IRD, ixazomib, lenalidomide, dexamethasone.