An increasing number of driver abnormalities is associated with poor prognosis. (A) Bar plot of number of mutated driver genes per sample; 203 samples (15.9%) did not contain any nonsynonymous single-nucleotide variants or indels in any of the 63 driver genes; 1070 samples (84.1%) contained ≥1 mutation, 700 samples (55.0%) contained ≥2 mutations, 351 samples (27.6%) contained ≥3 mutations, and 151 samples (11.9%) contained ≥4 mutations (N = 1273). (B) The distribution of all driver abnormalities identified per sample. The number of drivers per sample was calculated using the drivers listed in (supplemental Table 7). Each marker counts for a score of 1; score summed for each patient; maximum score = 91, because some drivers were mutually exclusive (eg, IG translocations), and some copy number features were summarized as a chromosomal arm alteration. The median number of drivers per sample was 5, with a range of 0 to 24. (C) Progression-free survival of patients was significantly negatively affected as the number of drivers increased (P < .001; N = 1273). (D) Overall survival of patients was significantly negatively affected as the number of drivers increased (P < .001; N = 1273).