X-ray crystal structure of the FVIII C2 domain/3E6 FAB/G99 FAB ternary complex. (A) Ribbon diagram presentation of the ternary complex determined to 2.47 Å resolution (pdb# 4KI5); red: fVIII C2 domain, blue: 3E6 F_AB heavy chain, cyan: 3E6 F_AB light chain, dark green: G99 F_AB heavy chain, light green: G99 F_AB light chain. (B) Rigid body modeling of the ternary crystal structure into the previously calculated SAXS-derived molecular envelope (colors same as in A). (C) Superposition of different x-ray crystal structures of the fVIII C2 domain. Red: ternary complex C2 domain (pdb# 4KI5), blue: pdb# 1D7P, green: pdb# 3HNB, cyan: pdb# 3HNY, magenta: pdb# 3HOB. The side chains of solvent exposed hydrophobic loops are displayed (Met2199, Phe2200, Leu2251, Leu2252).