Model of progression of 7 cases of DS-related TMD/AMKL. Boxes indicate the genes with putative driver mutations. Genes in bold type are common with other leukemias; those in italics are not reported in leukemia, but in other types of malignancy. Red bars indicate the time point at which the tumor sample was taken. Numbers indicate percentages of leukemic cells based on the quantifications of reads with the somatic mutations from exome sequencing. Tumors presented in blue are self-regressed TMDs, and those in green are AMKLs. T21-HP, hematopoietic precursors with trisomy 21; ?, for AMKLs 15 and 16, a TMD sample was not available and it is unknown whether there were mutations acquired in this phase.