OxLDL induces CD36-signaling pathways leading to MLC phosphorylation and change in platelet shape. Diagrammatic representation of the signaling pathways induced by oxLDL, leading to platelet shape change. OxLDL stimulates platelets through CD36 leading to a Src kinase–dependent activation of Syk and PLCγ2, which results in an increase in intracellular Ca²⁺ levels and activation of MLCK. Simultaneously, a Src kinase–dependent activation of RhoA is initiated, resulting in ROCK activation and inhibition of MLCP inhibition. These events culminate in the phosphorylation of MLC and platelet shape change.