BMP9-regulated genes, known to be involved in lymphatic valve development, in LECs. LECs were stimulated in serum-free medium in the absence or in the presence of 10 ng/mL BMP9 for the indicated times. Expression of HPRT was used to normalize the samples. The results are represented as mRNA fold changes measured in BMP9-treated cells vs nontreated cells at each time point. Data are the mean ± SE from 4 independent experiments performed in duplicate. *P ≤ .05, significantly different from respective controls by Mann-Whitney U test.