Role of R2-MRI in the quantification of LIC in HCT recipients. GVHD, graft-versus-host disease. Iron overload: transfusion, dyserythropoiesis, associated genetic factors (HEF mutations); Non-iron-overload etiology: inflammation (GVHD, infections, radiation), metabolic syndrome (immunosuppression), hepatitis (viral, drugs, GVHD, radiation), associated ETOH usage; *Elevated ferritin; †LIC predicts body iron stores, changes in LIC show changes body iron with chelation therapy, calculate iron balance, predicts risk of hepatic complications and risk of extra-hepatic complications. Liver R2 panels are reproduced from Figure 4 in St Pierre et al² by permission.