Proposed model for JARID1B activity in modulation of HSC fate. Gray shaded area: JARID1B erases the tri-methyl marks of H3K4 at stemness loci and represses activity of multipotency genes. Pink area: Decrease in JARID1B activity shifts balance in favor of histone methylases, preserving the active H3K4me3 mark at stemness loci to sustain multipotency.