Figure 2
Figure 2. UHF and LMWH inhibit platelet-mediated angiogenic response. (A) Endothelial cell migration after exposure to the releasate from control, resting platelets (Plts) or platelets activated with 25 μM ADP after exposure to UFH. (B) Quantification of branch points generated by the releasate from resting platelets or platelets activated with 25 μM ADP or stimulation with MCF-7 cells after exposure to UFH. (C) Endothelial cell migration after exposure to the releasate from control, resting platelets (Plts) or platelets activated with 25 μM ADP or stimulation with MCF-7 cells after exposure to LMWH. (D) Quantification of branch points generated by the releasate from resting platelets or platelets activated with 25 μM ADP after exposure to LMWH. (E) Representative images of capillary tube formation generated from the releasate of resting platelets or platelets exposed to ADP or MCF-7 cells with or without LMWH or UFH. *P < .05. Bars represent 100 μM.

UHF and LMWH inhibit platelet-mediated angiogenic response. (A) Endothelial cell migration after exposure to the releasate from control, resting platelets (Plts) or platelets activated with 25 μM ADP after exposure to UFH. (B) Quantification of branch points generated by the releasate from resting platelets or platelets activated with 25 μM ADP or stimulation with MCF-7 cells after exposure to UFH. (C) Endothelial cell migration after exposure to the releasate from control, resting platelets (Plts) or platelets activated with 25 μM ADP or stimulation with MCF-7 cells after exposure to LMWH. (D) Quantification of branch points generated by the releasate from resting platelets or platelets activated with 25 μM ADP after exposure to LMWH. (E) Representative images of capillary tube formation generated from the releasate of resting platelets or platelets exposed to ADP or MCF-7 cells with or without LMWH or UFH. *P < .05. Bars represent 100 μM.

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