Cyclin-dependent kinase inhibitor genes and antioxidant-related genes are markedly downregulated in mortalin-KD HSCs. Expression of (A) cell cycle–related genes and (B) oxidative stress regulatory genes in GFP⁺ donor-derived LSK cells at 4 months posttransplantation, as assessed by qRT-PCR. β-actin was used as an endogenous control. Data represent the mean ± SD (**P < .01, ***P < .001).