Blood cell parameters in JAK2V617F KI mice. Blood parameters from KI (filled circles, n = 5-41) and WT littermate (open circles, n = 5-24) mice were studied from 2 weeks of age to over 6 months of age. Values were grouped to the closest month. Hematocrit values at 2-3 months were 70 ± 2% n = 13, controls 49 ± 1% n = 13. Platelet numbers reach at 2 months 2.3 ± 0.1 × 109/mL, n = 31, controls 0.84 ± 0.04 × 109/mL, n = 20. WBCs remained high for 6 months (36 ± 2 × 106/mL, n = 117, controls 8.0 ± 0.3 × 106/mL, n = 89). After 6 months, WBCs reached 77 ± 21 × 106/mL n = 5; controls: 8.7 ± 0.7 × 106/mL, n = 8; but platelet decreased to subnormal levels (1.6 ± 0.21 × 109/mL, n = 5; controls 1.03 ± 0.09 × 109/mL, n = 8) along with hemoglobin levels (11.4 ± 1.2 g/L, n = 5, control values 14.7 ± 0.5 g/L, n = 8). Results are mean value ± SEM, *P ≤ .05 with the 2-tailed unpaired Student t test. MCV, mean corpuscular volume; MGV, mean globular volume; MPV, mean platelet volume.
