Effect of GM-6001 on leukocyte interstitial migration behavior. Leukocyte interstitial migration behavior was analyzed after perivenular microinjection of PAF or CCL3 as detailed in the “Methods” section. Panels show results for directionality (A, B), velocity (C, D), and accumulated distance (E, F) of interstitially migrating leukocytes in animals treated with the MMP inhibitor GM-6001 or vehicle (mean ± SEM for n = 4 per group; *P < .05 vs vehicle).