Figure 1
![Figure 1. JAK2 is required for initiation of MPLW515L-mediated disease. Deletion of Jak2 following engraftment of MPLW515L-transduced BM leads to significant reduction in (A) WBC counts, (B) platelets, (C) mutant allele burden in terms of GFP-positive cells in PB (P < .005), and (D) spleen (P < .05) and (E) liver size (P < .05) as compared with controls. (F) BM fibrosis assessed by reticulin staining is absent in Jak2-deleted BM. (Data are represented at mean ± standard error of the mean [SEM]; Jak2+/+, n = 4; Jak2−/−, n = 5).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/123/13/10.1182_blood-2014-01-547760/4/2075f1.jpeg?Expires=1735832258&Signature=Szz7GiTWRDj7urFVGBS6YbTEYq8INyDG--UR0f9T8aEwJmj5KSXJ8IqrVnC1sIJblpvvvswCbaXJu0x0HuNB1smBdQroDa4nSI3R~zbmVvRg9NEuxmp-3dZpnDRPN716jaf0F1Qz8vkCZ9Xpmay-IkoaXo4PISsLUYksDr6rkuF8-KBsPkopTAi93Kn7WJ7OSJ2gXApCQtPmERHU5qd3-kBEX-Q~k~ray1idPmdwY4ACqtXo4AnTSS-WoLslGWJNIb63OClbwcKY02NWIKx1Y98cLQ3MuUfrnobFFf9-qbyqu45ZRnSgr7D4CN9QffFHtViD-5950ibELfC6OrebHw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
JAK2 is required for initiation of MPLW515L-mediated disease. Deletion of Jak2 following engraftment of MPLW515L-transduced BM leads to significant reduction in (A) WBC counts, (B) platelets, (C) mutant allele burden in terms of GFP-positive cells in PB (P < .005), and (D) spleen (P < .05) and (E) liver size (P < .05) as compared with controls. (F) BM fibrosis assessed by reticulin staining is absent in Jak2-deleted BM. (Data are represented at mean ± standard error of the mean [SEM]; Jak2+/+, n = 4; Jak2−/−, n = 5).
