CD48 is specifically downregulatred by PML-RARA and AML1-ETO. (A-H) Flow cytometry analysis of various NK cell ligands expressed by U937 cells transduced with the 2 AML oncogenes: PML-RARA (A-D, black lines) or AML1-ETO (E-H, black lines) compared with U937 cells transduced with an empty vector (A-H, gray lines). Gray shaded histograms, background staining with an isotype-matched control antibody. One of at least 2 representative experiments performed (the staining of CD48 was repeated 8 times, the staining of ULBP1 and ULBP2 was repeated 3 times) is shown.