Perinucleolar relocalization of the der14 IgH and Ccnd1 alleles in the MCL Granta-519 cell line. The IgH and Ccnd1 alleles and nucleoli were revealed by immuno-FISH. (A) Distances to the closest nucleolus measured as described in Materials and methods for a minimum of 120 FISH signals. (B) A representative image of double-labeled DNA FISH in Granta-519 cell line. IgH is green, Ccnd1 is red, and nucleolus (B23) is blue. Scale bar represents 5 µm.