Sequence alignment of VWF CTCK to CTCK domains from other proteins and structural alignment to related proteins. Sequence alignment with MAFFT was with the G-INS-i strategy.³⁹  Structural alignment was with SSM⁴⁰ ; the alignment was then condensed, closing gaps in loop regions and preserving alignment in β-strands (overlined) and in cysteines. Sequence accessions are murine mucin5AC, GI:114431224; zebrafish otogelin, GI:326669509; Drosophila hemolectin, GI:24663920; human norrin, GI:4557789; Drosophila Slit, GI:17136482; human connective tissue growth factor, GI:49456477; human TGFβ2 GI:48429157; human noggin, GI:1117817; and human chorionic gonadotropin β-subunit, GI:132566538.