Frequency and distribution of acquired RUNX1 and CSF3R mutations and inherited ELANE, WAS, GFI1, GPT, and HAX1 mutations within a cohort of CN patients who developed leukemia or MDS. (A) Each patient with a RUNX1 mutation is represented by a blue rectangle, and each patient with a CSF3R mutation is represented by a green rectangle. Patients with inherited mutations are represented by orange rectangles. Open rectangles correspond to patients without mutations. (B) Venn diagram illustrating the relationship among RUNX1 and CSF3R mutations in CN patients who developed leukemia (n = 31). Diameters of each circle are roughly proportional to the number of mutations.