Cooccurrence of RUNX1 and CSF3R mutations in combination with monosomy 7 and trisomy 21 in a leukemic clone of a CN/AML patient. (A) Graphic presentation of a mutational analysis of deep-sequencing data for RUNX1 and CSF3R genes in CN/AML patient 14. Results of sequencing DNA samples from different time points prior to overt AML (x-axis) and the percentage of mutant clones (y-axis) are presented. (B) Diagram of the distribution of RUNX1 and CSF3R mutations in DNA isolated from single clones (n = 48) of AML samples from CN patient 14.