Management pathway for sickle hepatopathy. Note:1) Exercise caution in bilirubin interpretation in those with Gilbert's syndrome or G6PD deficiency; 2) At any stage, if patient is in fulminant failure for whatever cause, consideration of LT is dependent on patient and vital organ function; 3) For patients with non-SCD causes (eg, autoimmune hepatitis) and refractory to treatment, consider a regular EBT program; 4) Monitoring and management of iron overload essential as hepatic siderosis may exacerbate other causes of hepatic dysfunction; 5) Liver biopsy not indicated unless a genuine diagnostic dilemma; 6) Ursodeoxycholic acid may be considered to improve biliary sludging in cholestasis.