Figure 2
Histone modifications identify a far downstream Major Peak that shares with the Bcl11b promoter its patterns of histone marks. (A) Distinct epigenetic modification and gene expression patterns at the genomic region spanning Bcl11b and several downstream and upstream gene loci in T-cell precursors from DN1 to DN2b.9 Black arrow: Major Peak. The Major Peak displays similar dynamics of epigenetic modifications as Bcl11b. H3Ac: blue, H3K4me2: red, H3K27me3: green, RNA-seq: black. (y-axis units in RPM). (B) Epigenetic modification patterns at the same genomic region in EBF−/− pre-pro B cells.33
