Liver histology of a patient with chronic HEV. The histopathology of chronic HEV infection in this patient is characterized by a dense lymphoplasmocellular infiltrate (dashed arrow) in the portal tracts, combined with severe fibrosis (F3) and portoportal septation (*). Multiple foci of apoptotic bodies are seen in the lobuli surrounded by a few inflammatory cells, indicating individual hepatocyte necrosis (councilman bodies: arrow) and probably caused by viral replication.