Exome sequencing in MCL reveals recurrently mutated genes. (A) The heatmap indicates the pattern of nonsynonymous mutations of the 37 most significantly implicated genes in 56 cases of MCL. Each column represents a patient, and each row represents a gene. Mutations are color-coded with yellow for a missense mutation, purple for a frameshift mutation, red for a nonsense mutation, and orange for an in-frame insertion or deletion. (B) The bar graph indicates the frequency of variants found by gene across all samples, subdivided by not-synonymous (blue) and synonymous (gray) mutations. (C) The network indicates functional groupings of the genes mutated in MCL. Nodes represent significantly mutated genes that are also a part of a significant functional group. Edges connect nodes that belong to the same functional gene set. Colored ovals identify the gene sets to which these nodes belong.