Leukocyte extravasation was compromised in MK^−/−mice during hypoxia-mediated inflammation. (A) Representative histological sections of Mm. gastrocnemii from MK^+/+ or MK^−/− mice 4 days after ligation of the femoral artery in the right leg (occ) and sham operation of the left leg (sham). Immunohistochemical staining of CD45⁺ cells (red) indicated by arrows. Bar = 100 μm. (B) Quantitative analysis of leukocyte extravasation measured as CD45⁺ cells per visual field; n = 3 independent experiments. Diagram shows mean ± SEM. ***P < .001.