Partial karyotypes of patient 36 demonstrating similar but reconfigured CNs for 1q21 but a different CN for 17p in related clones. FISH probes 1q12 (red) and 1q21 (green), TP53 (green), and ERB2 (red) are shown. (A) In the first specimen, copies of JT1q12 were identified on both the 17p and 18p (top row, G-bands). FISH for 1q12 and 1q21 showed JT1q12 on both 17p and 18p with a 1q21 CN of 4 (middle row; normal chromosome 1 not shown). Probes for TP53 and ERB2 (bottom row) showed a CN of 1 for 17p. (B) In a second specimen analyzed 5 months later, normal chromosome 17 was identified by G-banding (top row), and a CN of 4 for 1q21 was found; however, both copies of JT1q12s were on the 18p (bottom row). This less-evolved clone indicates that the second copy of JT1q12 on the 18p in this clone is the JT1q12 that translocated to 17p, resulting in the deletion of TP53 in the previous specimen.