Inhibitor epitopes on the C2 domain. Binding sites of the 5 different types (A, AB, B, BC, and C) of anti-C2 domain antibodies are displayed. The orientation of the C2 domain is depicted below the image. For type AB and B antibodies, a bottom view of the C2 domain is shown. Image was prepared using the crystal structure of B domain-deleted FVIII (3cdz), using PyMOL.