ALA reduces platelet adhesion and aggregation to vWF under flow. Blood from human healthy donors was incubated with 7.5, 15, and 30 μM ALA or vehicle (ethanol) for 1 hour. Adhesion to vWF was quantified at a shear rate of 2500 s⁻¹ for 10 minutes with the Bioflux software. There was a dose-dependent reduction of platelet adhesion and aggregation that was significant for the highest ALA concentration used (D; n = 6; *P = .02).